| Autor: |
Reo IKUMI, Takayuki MIYAHARA, Norio AKINO, Noriko TACHIKAWA, Shohei KASUGAI |
| Předmět: |
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| Zdroj: |
Dental Materials Journal; 2018, Vol. 37 Issue 6, p912-918, 7p |
| Abstrakt: |
The effectiveness of a previously developed unsintered hydroxyapatite (uHA) and poly(L-lactic acid) (PLLA) hydrophilic membrane as a resorbable barrier for guided bone regeneration (GBR) was evaluated. Critical-size 8-mm diameter bone defects were surgically generated in the parietal bones of 24 12-week-old male Wistar rats, which were then divided into three groups in which either a uHA/PLLA or a collagen membrane or no membrane (control) was placed onto the bone defect. Following sacrifice of the animals 2 or 4 weeks after surgery, bone defects were examined using microcomputed tomography and histological analysis. Bone mineral density, bone mineral content, and relative bone growth area values 2 or 4 weeks after surgery were highest in the uHA/PLLA group. Four weeks after surgery, the relative bone growth area in the uHA/PLLA group was larger than that in the collagen group. The resorbable uHA/PLLA membrane is thus potentially effective for GBR. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
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