| Autor: |
Aluko-Olokun, Bayo, Olaitan, Ademola Abayomi, Adediran, Olanrewaju Moses |
| Zdroj: |
International Medical Journal; Aug2018, Vol. 25 Issue 4, p238-240, 3p |
| Abstrakt: |
Background: While seeking remedy for keloid through intralesional drug injection, it is important that the clinician prevents ulceration of the lesion, often caused by damage to skin overlying the lesion. Bleb formation or outright skin rupture results when the capacity of lesion to hold fluid-drug is exceeded; these lead to ulceration. Knowledge of the capacity of a lesion to hold liquid drug prior to intralesional injection may therefore be advantageous. This study investigates the maximum volume of liquid-drug a facial keloid lesion is able to hold without skin damage. Method: Pre-injection volume of keloid was taken. Bleb formation and outright skin rupture during injection procedure, were taken as signs that liquid-holding capacity of lesion had been reached and exceeded. Note was taken of the volume of triamcinolone suspension administered before bleb was formed or rupture of injected lesion occurred. Results: The average volume of injected drug was found to be 29% of lesion volume. A fairly constant relationship between volume of keloid and capacity to hold fluid-drug was found. Conclusion: Maximum volume of liquid drug which a keloid lesion should hold is about a quarter of its volume. This makes it advisable to measure the volume of lesions before every intralesional injection procedure, in order to avoid prolonged treatment period caused by injection complications leading to ulceration. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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