Shiatsu as an adjuvant therapy for depression in patients with Alzheimer's disease: A pilot study.

Autor: Lanza, Giuseppe, Centonze, Stella Silvia, Destro, Gera, Vella, Veronica, Bellomo, Maria, Pennisi, Manuela, Bella, Rita, Ciavardelli, Domenico
Zdroj: Complementary Therapies in Medicine; Jun2018, Vol. 38, p74-78, 5p
Abstrakt: Objectives: Among the complementary and alternative medicine, Shiatsu might represent a feasible option for depression in Alzheimer's disease (AD). We evaluated Shiatsu on mood, cognition, and functional independence in patients undergoing physical activity.Design: Single-blind randomized controlled study.Setting: Dedicated Community Center for patients with AD.Interventions: AD patients with depression were randomly assigned to the "active group" (Shiatsu + physical activity) or the "control group" (physical activity alone). Shiatsu was performed by the same therapist once a week for ten months.Main Outcome Measures: Global cognitive functioning (Mini Mental State Examination - MMSE), depressive symptoms (Geriatric Depression Scale - GDS), and functional status (Activity of Daily Living - ADL, Instrumental ADL - IADL) were assessed before and after the intervention.Results: We found a within-group improvement of MMSE, ADL, and GDS in the active group. However, the analysis of differences before and after the interventions showed a statistically significant decrease of GDS score only in the active group.Conclusions: The combination of Shiatsu and physical activity improved depression in AD patients compared to physical activity alone. The pathomechanism might involve neuroendocrine-mediated effects of Shiatsu on neural circuits implicated in mood and affect regulation. [ABSTRACT FROM AUTHOR]
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