Five-Year Follow-Up and Outcomes of Noninvasive Ventilation in Subjects With Neuromuscular Diseases.
| Autor: | Mi Ri Suh, Won Ah Choi, Dong Hyun Kim, Jang Woo Lee, Eun Young Kim, Seong-Woong Kang |
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| Předmět: |
AMYOTROPHIC lateral sclerosis treatment
TREATMENT of Duchenne muscular dystrophy MUSCLE disease treatment TREATMENT of spinal muscular atrophy NEUROMUSCULAR diseases PROGRESSIVE bulbar palsy AMYOTROPHIC lateral sclerosis ARTIFICIAL respiration BLOOD gases analysis OXIMETRY PROBABILITY theory QUALITY of life RESPIRATORY measurements STATISTICS TIME PULSE oximeters DATA analysis TREATMENT effectiveness CONTINUING education units DATA analysis software DESCRIPTIVE statistics MANN Whitney U Test KRUSKAL-Wallis Test DISEASE complications PSYCHOLOGY THERAPEUTICS DISEASE risk factors |
| Zdroj: | Respiratory Care; Mar2018, Vol. 63 Issue 3, p274-281, 8p, 1 Diagram, 3 Charts |
| Abstrakt: | INTRODUCTION: The purpose of this study was to investigate the 5-year outcomes of noninvasive ventilation (NIV) application in different neuromuscular disease (NMD) groups. METHODS: We categorized 180 subjects who had initiated NIV between March 2001 and August 2009 into 4 groups and followed them for > 5 y. The NIV maintenance rate and average duration, applying time, and forced vital capacity (FVC) were investigated at the time NIV was initiated and 5 y after NIV initiation in each group. RESULTS: In subjects with amyotrophic lateral sclerosis (ALS), Duchenne muscular dystrophy (DMD), and spinal muscular atrophy (SMA)-congenital myopathy, the 5-year subjects who continued to use NIV over time were 22.5%, 89.4%, and 91.3%, respectively, and the average NIV maintenance durations were 21.53 ± 19.26 months, 55.22 ± 11.47 months, and 57.48 ± 8.34 months, respectively (P < .001). Median daily applying time changed from 8.0 h to 24.0 h (P < .001), from 8.0 h to 12.0 h (P < .001), and from 8.0 h to 9.0 h (P = .11) in subjects with ALS, DMD, and SMA-congenital myopathy, respectively. FVC decreased significantly after 5 y except in the group with combined SMA-congenital myopathy. CONCLUSIONS: NIV was tolerated long-term without significant increases in daily application time for most subjects with NMD. However, in individuals with ALS, development of severe bulbar symptoms can risk maintaining NIV. [ABSTRACT FROM AUTHOR] |
| Databáze: | Supplemental Index |
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