| Autor: |
SPIRINA, Liudmila V., KONDAKOVA, Irina V., TARASENKO, Natalia V., SLONIMSKAYA, Elena M., USYNIN, Evgeny A., GORBUNOV, Alexey K., YURMAZOV, Zahar A., CHIGEVSKAYA, Svetlana Yu |
| Předmět: |
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| Zdroj: |
Chinese Journal of Lung Cancer; Jan2018, Vol. 21 Issue 1, p63-66, 4p |
| Abstrakt: |
Resistance to cancer therapy continues to be a major limitation for the successful treatment of cancer. There are many published studies on therapy resistance in breast and prostate cancers; however, there are currently no data on molecular markers associated with resistance. The conflicting data were reported regarding the AKT/m-TOR signaling pathway components as markers predicting resistance. The AKT/m-TOR signaling pathway is involved in the development of many human cancers; its activation is related to cell proliferation, angiogenesis, apoptosis, as well as to therapy resistance. Molecular alterations in the AKT/m-TOR signaling pathway provide a platform to identify universal markers associated with the development of resistance to cancer therapy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
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