| Autor: |
FU, X.-M., GUO, W., LI, N., LIU, H.-Z., LIU, J., QIU, S.-Q., ZHANG, Q., WANG, L.-C., LI, F., LI, C.-L. |
| Zdroj: |
European Review for Medical & Pharmacological Sciences; 2017, Vol. 21 Issue 14, p3239-3246, 8p |
| Abstrakt: |
OBJECTIVE: This study aimed to investigate the expression and clinical significances of long noncoding RNA-ATB (lncRNA- ATB) in papillary thyroid cancer (PTC) and to explore the roles of lncRNA-ATB in PTC cell proliferation and migration. PATIENTS AND METHODS: The expression of lncRNA-ATB in 64 PTC tissues and paired adjacent noncancerous thyroid tissues was measured. The association between lncRNA-ATB expression and clinicopathological characteristics was analyzed by Pearson X2. The diagnostic value of lncRNA-ATB was evaluated by receiver operating characteristic curve (ROC) analyses. The effects of lncRNA-ATB on PTC cell proliferation were evaluated by Cell Counting Kit-8 assays and Ethynyl deoxyuridine incorporation assays. The effects of lncRNA-ATB on PTC cell migration were evaluated by transwell assays. RESULTS: LncRNA-ATB is upregulated in PTC tissues compared with noncancerous tissues. LncRNA-ATB is also increased in PTC cell lines compared with normal thyroid follicular epithelial cell line. High-expression of lncRNA-ATB is associated with large tumor size and lymph node metastasis. ROC analyses revealed that lncRNA-ATB could sensitively discriminate PTCs from noncancerous tissues, as well as discriminating PTCs with lymph node metastasis from those without lymph node metastasis. Functional experiments showed that depletion of lncRNA-ATB significantly inhibits PTC cell proliferation and migration.CONCLUSIONS: LncRNA-ATB is upregulated and functions as an oncogene in PTC. Furthermore, lncRNA-ATB may serve as a diagnostic biomarker and therapeutic target for PTC. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
