A Facile Synthesis of 2,4-Disubstituted 3-Fluoroquinolines via Intramolecular Cyclization of o-Cyanomethylamino-β,β-difluorostyrenes.

Autor: Wada, Yukinori, Mori, Takashi, Ichikawa, Junji
Předmět:
Zdroj: Chemistry Letters; 11/5/2003, Vol. 32 Issue 11, p1000-1001, 2p, 1 Diagram, 1 Chart
Abstrakt: o-Cyanomethylamino-β,β-difluorostyrenes are treated with base (LiTMP, Nail, or K[sub2]CO[sub3]) to generate the corresponding carbanions, which in turn readily undergo intramolecular replacement of the vinylic fluorine and subsequent elimination to afford 2,4-disubsfituted 3-fluoroquinolines in good yield. [ABSTRACT FROM AUTHOR]
Databáze: Supplemental Index