| Autor: |
Khokhar, Tahira S., Memon, Shahabuddin, Panhwar, Qadeer K., Memon, Fakhar N., Memon, Ayaz A., Samejo, Muhammad Qasim, Muneer, Saba, Tulu, Metin |
| Zdroj: |
Pakistan Journal of Pharmaceutical Sciences; May2017, Vol. 30 Issue 3, p783-788, 6p, 1 Diagram, 2 Charts, 7 Graphs |
| Abstrakt: |
Complexation of ibuprofen with water soluble p-sulfonatocalix[4]arene (3) was evaluated. Both molecules exhibit a host and guest type complexation. pH, complex stoichiometry and binding constant were determined by UV-Vis and FT-IR spectroscopy. The maximum complexation of 3 with ibuprofen occurs at pH 2. Stability constant values (9.897) show that there is favorable complex formed due to vital role of p-sulfonatocalix[4]arene, while the thermodynamic parameters, i.e. ΔG, ΔH and ΔS have been found as -24.09 KJ/mol, 0.012 KJ/mol and 0.12 KJ/mol. K, respectively. The results show that 3 has efficiency to carry the drug at particular conditions and can be used for drug delivery as a carrier. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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