Virus Capsid Coating of Gold Nanoparticles via Cysteine-Au Interactions and Their Effective Cellular Uptakes.

Autor: Keita Nagakawa, Kenichi Niikura, Tadaki Suzuki, Yasutaka Matsuo, Manabu Igarashi, Hirofumi Sawa, Kuniharu Ijiro
Zdroj: Chemistry Letters; 1/5/2012, Vol. 41 Issue 1, p113-115, 3p
Abstrakt: This manuscript describes the synthesis of virus capsid protein-coated Au nanoparticle (VPAuNP) without the use of the inherent self-assembly of virus proteins into virus particles. Covalent binding between Au and cysteines in the virus proteins keep the cell-surface binding sites on the external surface. Based on this method, various sizes of VPAuNP can be created in a similar manner to native virus particles. We clarified the optimum size of the VPAuNP for internalization into cells. [ABSTRACT FROM AUTHOR]
Databáze: Supplemental Index