| Autor: |
Domnişor, Liliana, Negru, I., Tacu, D., Bucşa, C., Gîngu, C., Baston, C., Hârza, M., Manea, I., Dudu, C., Preda, A., Ismail, G., Sinescu, I. |
| Předmět: |
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| Zdroj: |
Romanian Journal of Urology; 2016, Vol. 15 Issue 1, p33-37, 5p |
| Abstrakt: |
Introduction. Delayed graft function (DGF) is one of the most commonadverse event affecting kidney allografts immediately after transplant surgerywith detrimental effect upon short and long graft survivaland several risk factors were associated with its presence. However, data concerning the impact of warm ischemia time on DGF are contradictory. The aim of this study was to analyse the influence of warm ischemia time for DGF and to determine whether simultaneously prolonged cold ischemia time and warm ischemia time were associated with DGFin recipients of kidneys from deceased donors at our center. Materials and Methods. This prospective observational study included a series of 143 consecutive deceased donor renal transplants performed in our center beetwen 1st of January 2014 and 30th of September 2015. The study endpoint was DGF, defined as the requirement of dialysis in the first week after transplantation. Results. DGF occured in 21 kidney recipients from deceased donors (14.7%). Univariate analysis showed that recipient dialysis time before transplantation and recipient comorbidities were associated with DGF, whereas recipient age at transplantation, donor age and donor serum creatinine were not. As for the post renal transplant factors, prolonged cold ischemia time and the intensive care support time prior to aortic cross-clamping were associated with an increased risk of DGF, while prolonged warm ischemia time was not. The simultaneously prolonged cold ischemia time and warm ischemia time were associated with DGF (p <0.001), suggesting some cumulative effects on postoperative renal graft function. Conclusions. In our study, warm ischemia time was not associated with increased risk of DGF. However, simultaneously prolonged cold ischemia time and warm ischemia time were associated with DGF. Despite improvements in kidney transplantation, DGF remains an important medical problem and more risk factors should be investigated to help clinicians to decrease its incidenceand minimize clinical outcomes. [ABSTRACT FROM AUTHOR] |
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