| Autor: |
Jun Oshitani, Natsumi Murakami, Mikio Yoshida, Naoyuki Ishida, Koreyoshi Imamura, Hideki Ichikawa |
| Zdroj: |
Chemistry Letters; 7/5/2014, Vol. 43 Issue 7, p1011-1013, 3p |
| Abstrakt: |
The yield and size distribution of surfactant-free solid lipid nanoparticles (SF-SLNs) formed by hot homogenization were investigated by changing the amount of lipid (palmitic acid). The yield was 100% and monodispersed same-sized particles of 120-200 nm were formed at the lipid amount ≤2.8 × 10-4 g-lipid (g-water)-1. The yield decreased owing to phase separation, and the size increased "step-likely" to be 200-350 nm while keeping the monodispersity when the lipid amount was just above 2.8 × 10-4 g-lipid (g-water)-1. The size and the lipid amount continued to increase gradually at the lipid amount >2.8 × 10-4 g-lipid (g-water)-1. The results indicate that submicron-sized solid lipid particles can be formed without surfactants and that the decrease of yield and the step-like increase of particle size occur at the same lipid amount. The total surface area of the SF-SLNs was estimated using the experimental data. It is suggested that the total surface area and the lipid amount are correlated to each other. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
