| Autor: |
Jing Wang, Mei-Juan Zou, Lei Chen, Yi-Ling Sheng, Xiao-Mian Zhou, Xiang-Rong Zhang |
| Zdroj: |
Pakistan Journal of Pharmaceutical Sciences; Nov2016, Vol. 29 Issue 6, p1997-2004, 8p, 1 Diagram, 7 Charts, 5 Graphs |
| Abstrakt: |
The objective of this work is to synthesize indolacin-5-fluorouracil-1-ylmethyl ester and the structure was confirmed by means of UV, IR, ¹H-NMR, 13C-NMR and mass spectrometry. The physicochemical parameters of melting point, solubility, apparent partition coefficient were investigated. S180 sarcoma, H22 hapatitic cancer and Lewistransplanted mice were used to evaluate the anti-tumor activity of indolacini-5-fluorouracil-1-ylmethyl ester compared with 5-fluorouracil in vivo. Anti-inflammatory and analgesic activities were evaluated in mice. The inhibitory ratio of indolacini- 5-fluorouracil-1-ylmethyl ester is comparative to that of 5-fluorouracil. This study indicates that 5-fluorouracil-1-ylmethyl ester may represent a new anticancer predrug of 5-fluorouracil to produce a combined effect of indolacin and 5-fluorouracil for cancer therapy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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