| Autor: |
Kazutaka KANAI, Sho NAGATA, Takuya HATTA, Yuichi SUGIURA, Kazuaki SATO, Yohei YAMASHITA, Yuya KIMURA, Naoyuki ITOH |
| Předmět: |
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| Zdroj: |
Journal of Veterinary Medical Science; Aug2016, Vol. 78 Issue 8, p1381-1384, 4p, 2 Charts, 1 Graph |
| Abstrakt: |
The present study aimed to investigate the therapeutic efficacy of post-inflammatory treatment with luteolin on endotoxin-induced uveitis (EIU) in rats. Intraperitoneal injection of 10 mg/kg luteolin or 1 mg/kg prednisolone (Pred) at 4 hr post-lipopolysaccharide (LPS) injection (200 μg) was associated at 24 hr post-LPS injection with decreased clinical severity scores, number of inflammatory cells, protein levels and levels of tumor necrosis factor (TNF)-α, nitric oxide (NO) and prostaglandin (PG) E2 in the aqueous humor (AqH) and degrees of histological ocular tissue injury. The anti-inflammatory potency of luteolin was comparable to that of Pred. Luteolin exhibited robust efficacy in the treatment of EIU in rats, indicating its potential clinical utility in treating uveitis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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| Externí odkaz: |
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