Pharmacokinetics and Bioavailability of Long Acting Moxifloxacin in Sheep.

Autor: Modi, C. M., Mody, S. K., Patel, H. B.
Zdroj: Indian Veterinary Journal; May2016, Vol. 93 Issue 5, p30-32, 3p
Abstrakt: Long acting moxi? oxacin is the fourth generation fluoroquinolone. In recent years long acing moxi? oxacin is one of the broadly used fluoroquinolone in veterinary medicine. It is active against organisms Gram-positive and Gram-negative bacteria, anaerobes and atypical organism such as Mycoplasma and Chlamydia spp (Dalhoff et al., 1996). This makes them an important antibacterial agent in the treatment of animal infections. Long acting moxifloxacin is having interesting disposition characteristics such as a wide spectrum of bactericidal activity, a large volume of distribution, low plasma protein binding and relatively low MICs against susceptible target microorganisms (Spreng et al., 1995; Brown, 1996). As the effectiveness of an antibacterial agent depends on its efficacy, bioavailability and pharmacokinetic disposition in the target animal, the aim of the present study was to investigate the bioavailability of long acting moxifloxacin in sheep. [ABSTRACT FROM AUTHOR]
Databáze: Supplemental Index