Inspiratory Muscle Weakness is Associated With Exercise Intolerance in Patients With Heart Failure With Preserved Ejection Fraction: A Preliminary Study.

Autor: KENSAKU YAMADA, YOSHIHARU KINUGASA, TAKESHI SOTA, MARI MIYAGI, SHINOBU SUGIHARA, MASAHIKO KATO, KAZUHIRO YAMAMOTO, Yamada, Kensaku, Kinugasa, Yoshiharu, Sota, Takeshi, Miyagi, Mari, Sugihara, Shinobu, Kato, Masahiko, Yamamoto, Kazuhiro
Zdroj: Journal of Cardiac Failure; Jan2016, Vol. 22 Issue 1, p38-47, 10p
Abstrakt: Background: The relationship between inspiratory muscle weakness (IMW) and exercise intolerance in patients with heart failure with preserved ejection fraction (HFpEF) remains unestablished.Methods and Results: The present study enrolled 40 patients with HFpEF (EF ≥45%). IMW was defined as maximum inspiratory pressure <70% normal predicted values. The function of the diaphragm was assessed by means of ultrasound measurement of muscle thickening of the diaphragm. IMW was prevalent in 27.5% of patients. Patients with IMW had significantly lower vital capacity relative to normal predicted values (%VC), lower knee extensor muscle strength in relation to body weight (%KEMS), poorer nutritional status as assessed by means of the Geriatric Nutritional Risk Index, and shorter 6-minute walk distance (6MWD) compared with patients without IMW (all P < .05). Impaired diaphragm muscle thickening at end-inspiration (median value < 3.9 mm) was significantly associated with a high prevalence of IMW and reduced 6MWD (all P < .05). Subgroup analysis showed that IMW was accompanied by a further decrease in 6MWD in patients with restrictive pulmonary dysfunction (%VC <80%) or lower-limb muscle weakness (median %KEMS <30%; all P < .05).Conclusions: IMW is associated with exercise intolerance in patients with HFpEF. [ABSTRACT FROM AUTHOR]
Databáze: Supplemental Index
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