| Abstrakt: |
Modafinil was administered as part of a treatment regimen in patients (N = 237) with a broad spectrum of treatmentresistant psychiatric, neurological and general medical disorders accompanied by some combination of excessive sleepiness, fatigue, executive dysfunction, and apathy. In a retrospective chart review of these patients, Clinical Global Impression of Severity (CGI-S) scores were evaluated. Most patients (84.4%) showed improvement in overall clinical condition with modafinil. Most patients tolerated this agent well; the most frequently reported adverse events were overstimulation, insomnia, headaches, and gastrointestinal distress. Modafinil may offer clinical benefit for treatmentresistant hypoarousal symptoms in a number of psychiatric, neurological and general medical conditions. [ABSTRACT FROM AUTHOR] |
