| Abstrakt: |
We discuss two cases of patients affected by pancreatic cysts and two patients affected by cystic fibrosis showing similar neuroautonomic profile, high adrenal sympathetic activity plus low neural sympathetic activity, who were significantly improved with neuropharmacological manipulations addressed to reverse this profile. Clinical, radiological, and neurochemical assessment showed progressive and sustained improvement throughout more than two years for the cystic fibrosis cases and lasted more than four years for the pancreatic cyst cases in the follow up of both trials. The neuropharmacological therapy addressed to enhance central noradrenergic activity was carried out by the administration of doxepin (noradrenaline uptake inhibitor). Our findings are consistent with the postulation that both syndromes share a common pathophysiological disorder, acinar secretory overflow, which overwhelms the pancreatic duct drainage. Although we have assessed and treated several patients with these pathologies, we refer only to these four well investigated, treated, and followed-up patients. [ABSTRACT FROM AUTHOR] |
