Circulating serotonin, catecholamines, and central nervous system circuitry related to some cardiorespiratory, vascular, and hematological disorders.

Autor: Lechin F, Van der Dijs B, Lechin AE
Zdroj: Journal of Applied Research; 2005, Vol. 5 Issue 4, p605-621, 17p
Abstrakt: This review presents results that show that assessment of circulating neurotransmitters is the most effective and, indeed imperative, way to attain a scientific approach to the autonomic nervous system (ANS). The resulting ANS profile makes it possible to prescribe neuropharmacologic therapies to correct central nervous system circuitry disorders responsible for the abnormalities registered at the peripheral ANS level. Some examples of disastrous therapeutic trials based on poor knowledge of neuropharmacology and the ANS in general are provided. In addition, data regarding the protagonist role exerted by circulating plasma serotonin in pulmonary bronchoconstriction, pulmonary vasoconstriction, and platelet serotonin in both cardiovascular and hematological disorders are given. All of these disorders were dramatically improved by the administration of neuropharmacologic agents that affected both platelet and neuronal serotonin uptake. [ABSTRACT FROM AUTHOR]
Databáze: Supplemental Index