| Autor: |
Bienaimé F, Clerbaux G, Plaisier E, Mougenot B, Ronco P, Rougier JP |
| Zdroj: |
American Journal of Kidney Diseases; Nov2007, Vol. 50 Issue 5, p821-825, 5p |
| Abstrakt: |
Several drugs, including hydralazine and propylthiouracil, can induce antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. d-Penicillamine was implicated in a few patients with rheumatoid arthritis or systemic sclerosis, but in patients with both diseases, ANCA-associated vasculitides were described in the absence of the drug. Therefore, the role of d-penicillamine treatment could not be established. We report the first case of antimyeloperoxidase antibody-associated vasculitis in a patient treated with d-penicillamine for Wilson disease. Because Wilson disease was never associated with ANCA-related nephritis, this case strongly supports that d-penicillamine can induce ANCA-vasculitis. The presentation and rapidly progressive and potentially severe outcome of this complication dramatically contrast with those of membranous and minimal change glomerulopathy, also induced by the sulfhydryl compound. Copyright © 2007 by Elsevier Inc. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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