| Autor: |
Meijerink MR, van Waesberghe JH, van der Weide L, van den Tol P, Meijer S, Comans EF, Golding RP, van Kuijk C, Meijerink, Martijn R, van Waesberghe, Jan Hein T M, van der Weide, Lineke, van den Tol, Petrousjka, Meijer, Sybren, Comans, Emile F, Golding, Richard P, van Kuijk, Cornelis |
| Zdroj: |
Academic Radiology; Oct2009, Vol. 16 Issue 10, p1215-1222, 8p |
| Abstrakt: |
Rationale and Objectives: The aim of this study was to prospectively evaluate the feasibility of a novel total liver volume perfusion computed tomographic technique in demonstrating treatment-site recurrence of liver metastases after radiofrequency ablation (RFA). Materials and Methods: Eleven patients considered to be at increased risk for local RFA-site tumor recurrence underwent both positron emission tomography (PET) and perfusion computed tomography (CTP): a 12-phase scan of the entire liver acquired before and 11 times after contrast injection. After coregistration, blood flow maps were created using the maximum slope method. Results: In all cases, the CTP-derived blood flow maps fully paralleled the PET images in showing either the absence (nine of 13 lesions) or presence (four of 13 lesions) of local RFA-site recurrence. Marginal lesions with high hepatic arterial perfusion (>50 mL/min/100 g) and low portal venous perfusion (<10 mL/min/100 g) represented recurring vital tumor tissue (P < .05). Conclusion: Total liver volume CTP seems feasible for the detection and localization of treatment-site recurrence after RFA. [ABSTRACT FROM AUTHOR] |
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