| Autor: |
Chan KT, Tye GA, Popat RA, Kuo WT, Unver K, Kothary N, Sze DY, Hofmann LV |
| Zdroj: |
American Journal of Obstetrics & Gynecology; Dec2011, Vol. 205 Issue 6, p537.e1-6, 1p |
| Abstrakt: |
OBJECTIVE: The objective of the study was to determine whether women with significant left common iliac vein stenosis who also use combined oral contraceptives (COCs) have a combined likelihood of deep vein thrombosis (DVT) greater than each independent risk. STUDY DESIGN: This was a case-control study comparing 35 women with DVT against 35 age-matched controls. Common iliac vein diameters were measured from computed tomography and magnetic resonance imaging. Logistic regression modeling was used with adjustment for risk factors. RESULTS: DVT was associated with COC use (P = .022) and with increasing degrees of common iliac vein stenosis (P = .004). Compared with women without venous stenosis or COC use, the odds of DVT in women with a 70% venous stenosis who also use COCs was associated with a 17-fold increase (P = .01). CONCLUSION: Venous stenosis and COC use are independent risk factors for DVT. Women concurrently exposed to both have a multiplicative effect resulting in an increased risk of DVT. We recommend further studies to investigate this effect and its potential clinical implications. [ABSTRACT FROM AUTHOR] |
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