Inhibitory effect of asiatic acid on acetylcholinesterase, excitatory post synapticpotential and locomotor activity.

Autor: Nasir MN, Abdullah J, Habsah M, Ghani RI, Rammes G
Zdroj: Phytomedicine; Feb2012, Vol. 19 Issue 3/4, p311-316, 6p
Abstrakt: The asiatic acid, a triterpenoids isolated from Centella asiatica was used to delineate its inhibitory effect on acetylcholinesterase (AChE) properties, excitatory post synaptic potential (EPSP) and locomotor activity. This study is consistent with asiatic acid having an effect on AChE, a selective GABA(B) receptor agonist and no sedative effect on locomotor. [ABSTRACT FROM AUTHOR]
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