Gender-specific differences in carotid intima-media thickness and its progression over three years: a multicenter European study.

Autor: Kozàkovà M, Palombo C, Morizzo C, Nolan JJ, Konrad T, Dekker JM, Balkau B, Nilsson PM, Kozàkovà, M, Palombo, C, Morizzo, C, Nolan, J J, Konrad, T, Dekker, J M, Balkau, B, Nilsson, P M
Zdroj: Nutrition, Metabolism & Cardiovascular Diseases; Feb2013, Vol. 23 Issue 2, p151-158, 8p
Abstrakt: Background and Aims: This multicentre European study evaluated, in a young-to-middle-aged healthy population without carotid atherosclerosis, the gender-related differences in carotid intima-media thickness (IMT) and its short-term (3-year) progression, and whether these differences are related to different vascular ageing rate, cardiovascular risk profile or different susceptibility to family predisposition to cardiovascular diseases (CVD). Methods and Results: 366 men and 422 women (age between 30 and 60 years) underwent B-mode carotid ultrasound at baseline and after 3-year follow-up period. IMT in 3 carotid segments was higher in men than in women (p < 0.0001 for all segments). When evaluated according to age decade, differences between men and women disappeared in the 6th decade, as in this decade a 3-year IMT progression rate accelerated in women (p < 0.05 as compared to the 4th and 5th age decade). Age was a major determinant of baseline all-segment IMT in women; in men all-segment IMT was influenced by age and LDL-cholesterol. IMT progression did not correlate with established cardiovascular risk factors, their short-term changes or family predisposition to CVD. Yet, a 3-year IMT progression in common carotid artery (CCA) was higher in men (p = 0.01) and women (p < 0.01) in whom relative Framingham risk increased during the corresponding period. Conclusion: This study provides reference values on IMT and its short-term progression in healthy young-to-middle-aged population, and demonstrates gender-related differences in the susceptibility of carotid wall to ageing and LDL-cholesterol. Increase in Framingham risk accelerated a short-term CCA IMT progression rate in both genders, whereas family predisposition to CVD did not influence carotid IMT. [ABSTRACT FROM AUTHOR]
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