Expression and localization of osteopontin, homing cell adhesion molecule/CD44, and integrin [alpha]v[beta]3 in mucoepidermoid carcinoma and acinic cell adenocarcinoma of salivary gland origin.

Autor: Fok, T C, Lapointe, H, Tuck, A B, Chambers, A F, Jackson-Boeters, L, Daley, T D, Darling, M R
Zdroj: Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology; Sep2014, Vol. 118 Issue 3, p320-329, 10p
Abstrakt: OBJECTIVE: Osteopontin (OPN) plays a role in tumor progression. This study aimed to determine the expression of OPN, CD44, and integrin [alpha]v[beta]3 in pleomorphic adenoma (PA), acinic cell adenocarcinoma (ACA), and mucoepidermoid carcinoma (MEC). STUDY DESIGN: Immunohistochemistry was used to semiquantify the levels of expression of OPN and its receptors in normal salivary glands (NSG) (n = 20), PA (n = 20), ACA (n = 11), and MEC (n = 29). RESULTS: OPN expression was increased in ACA and MEC compared with PA and NSG (median scores, 6, 6, 4, and 4, respectively). CD44 expression was increased in ACA and reduced in MEC and PA compared with NSG (median scores, 8, 4, 3, and 5, respectively). Integrin [alpha]v[beta]3 median scores were 5 in ACA, 1 in MEC, and 0 in PA and NSG. CONCLUSIONS: OPN is expressed in salivary gland tumors and is at higher levels in ACA and MEC. [ABSTRACT FROM AUTHOR]
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