| Autor: |
Bragadeeswaran, Subramanian, Kumaran, Nadarajah Sri, Pandimuthu, Lakshmanan, Prabahar, Rajagopal |
| Předmět: |
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| Zdroj: |
Journal of Basic & Clinical Physiology & Pharmacology; May2015, Vol. 26 Issue 3, p265-273, 9p |
| Abstrakt: |
Background: The present investigation was undertaken to evaluate the physiological characteristics of crab egg mass ( Portunus sanguinolentus) crude extract. Methods: Assays were followed by standard methods. Results: A maximum of 256 hemolytic units (HU) and a minimum of 128 HU were found in chicken and goat erythrocytes. In an antimicrobial assay, Salmonella paratyphi and Aspergillus niger showed most susceptibility (8.0 mm and 13.0 mm) against n-butanol extracts. In the tail flick method, 5.33±0.19* AR the maximum analgesic response was recorded 30 min after the administration of crude extract (150 mg kg-1). In the hot plate method, 5.13±0.13* AR maximum paw licking was recorded 15 min after the administration of crude extract (150 mg kg-1). In an anti-inflammatory assay, 0.31±0.23* anti-inflammatory response and inhibition of paw edema 39.22% were observed 1 h after the administration of crude extract (250 mg kg-1). Primary structural groups gained through Fourier transformed infrared (FTIR) analysis peaks were observed and assigned as amide groups I (1517.81-1633.12 cm-1), II (1446.58-1517.81 cm-1) and III (1342.47-1406.85 cm-1). Conclusions: The results indicate that crab egg masses have remarkable antimicrobial, hemolytic and cytotoxic activities. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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