Discovery of N-(2,4-Di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide(VX-770, Ivacaftor), a Potent and Orally Bioavailable CFTR Potentiator.
| Autor: | Hadida, Sabine, Van Goor, Fredrick, Zhou, Jinglan, Arumugam, Vijayalaksmi, McCartney, Jason, Hazlewood, Anna, Decker, Caroline, Negulescu, Paul, Grootenhuis, Peter D. J. |
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| Zdroj: | Journal of Medicinal Chemistry; Dec2014, Vol. 57 Issue 23, p9776-9795, 20p |
| Databáze: | Supplemental Index |
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