| Autor: |
Pietropaoli, Davide, Del Pinto, Rita, Corridoni, Daniele, Rodriguez‐Palacios, Alexander, Di Stefano, Gabriella, Monaco, Annalisa, Weinberg, Aaron, Cominelli, Fabio |
| Předmět: |
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| Zdroj: |
Journal of Periodontology; Dec2014, Vol. 85 Issue 12, p1799-1805, 7p |
| Abstrakt: |
Background: Oral involvement is often associated with inflammatory bowel disease (IBD). Recent evidence suggests a high incidence of periodontal disease in patients with Crohn disease (CD). To the best of the authors' knowledge, no animal model of IBD that displays associated periodontal disease was reported previously. The aim of this study is to investigate the occurrence and progression of periodontal disease in SAMP1/YitFc (SAMP) mice that spontaneously develop a CD-like ileitis. In addition, the temporal correlation between the onset and progression of periodontal disease and the onset of ileitis in SAMP mice was studied. Methods: At different time points, SAMP and parental AKR/J (AKR) control mice were sacrificed, and mandibles were prepared for stereomicroscopy and histology. Terminal ilea were collected for histologic assessment of inflammation score. Periodontal status, i.e., alveolar bone loss (ABL) and alveolar bone crest, was examined by stereomicroscopy and histomorphometry, respectively. Results: ABL increased in both strains with age. SAMP mice showed greater ABL compared with AKR mice by 12 weeks of age, with maximal differences observed at 27 weeks of age. AKR control mice did not show the same severity of periodontal disease. Interestingly, a strong positive correlation was found between ileitis severity and ABL in SAMP mice, independent of age. Conclusions: The present results demonstrate the occurrence of periodontal disease in a mouse model of progressive CD-like ileitis, in addition, the severity of periodontitis strongly correlated with the severity of ileitis, independent of age, suggesting that common pathogenic mechanisms, such as abnormal immune response and dysbiosis, may be shared between these two phenotypes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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