The Novel Route to Prepare Immobilized Macrocyclic Compound on 6-OH of Chitosan with Good Solubility and Prime Study on Its Applications.

Autor: Yu, Chen, Wei-Ping, Li, Yan-Chun, Ye, Yan-Wen, Guo, Tian-Wei, Wang, Yi-Fan, Xing
Předmět:
Zdroj: Molecular Crystals & Liquid Crystals; 2014, Vol. 604 Issue 1, p202-212, 11p
Abstrakt: β-cyclodextrin (β-CD) immobilization of a chitosan derivate on C6-OH (CTS-6-CD) with good solubility was prepared through a novel method. During the process the amino group of the chitosan was protected by phthalic anhydride and deprotected in the hydrazine hydrate solution. β-CD was immobilized onto the C6position of chitosan by a nucleophilic displacement reaction. The prepared derivate can be dissolved in hydrazine hydrate (v:v= 1:1), ethylenediamine/ethanol (v:v= 1:1), 1% aqueous acetic acid, DMSO and DMAc. The application of the 6-OH cyclodextrin-immobilized chitosan derivatives in an electrochemical biosensor was examined in a preliminarily manner. [ABSTRACT FROM PUBLISHER]
Databáze: Complementary Index