| Abstrakt: |
Background. Radiation therapy for breast cancer has been implicated in the development of bronchiolitis obliterans organizing pneumonia (BOOP).This inflammatory lung disorder was first noted in 1983, and there have been numerous reports ofBOOPoccurringinwomenwhohavehadradiationtherapyfor breast cancer since 1995.This studywas undertaken to perform a systematic reviewofpostradiotherapyBOOPtodetermine the occurrence, presentation, treatment, and outcome. Materials and Methods. A systematic literature review was conducted according to the guidelines provided by the Preferred ReportingItemsforSystematicReviewsandMeta-Analysesreport. Results. The literature search yielded 10 Japanese epidemiological reports with 129 women, 4 case series reports with 36 women, and 24 case reports with 34 women. Common symptoms included fever, cough, and shortness of breath. Most patients received corticosteroid therapy, and duration of treatment ranged from 6 months to 1 year, although some patients received steroids for longer than 1 year because of relapse, which occurred in approximately one half of patients. No deaths have been reported. Conclusion. BOOP is a rare but significant complication from radiation therapy for breast cancer. Chest radiographic studies for women who report new respiratory symptoms during the postradiation period can be beneficial for early diagnosis and for guiding appropriate management. [ABSTRACT FROM AUTHOR] |
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