| Autor: |
Sadiq, Heena, Ahuja, Puneet, Shivam, Animesh Kumar, R., Thanuja, Sharma, Bhudev, Yadav, Annu |
| Předmět: |
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| Zdroj: |
Journal of Oral & Maxillofacial Pathology (0973029X); 2014 Special Issue, Vol. 18, pS55-S55, 1/4p |
| Abstrakt: |
The proto-oncogene bcl2 is associated with follicular lymphoma involving translocation t (14;18) (q32;q21) and is also overexpressed in various neoplasms. Investigations into the sequential over-expression of the oncoproteins in oral epithelial dysplasia are lacking and the possible role of bcl2 in oral tumor progression remains unknown. Aim: To evaluate the expression of bcl2 in varying grades of Oral Epithelial Dysplasia. Materials and Methods: Immunohistochemical analyses were carried out in 30 cases of epithelial dysplasia,10 cases each of mild dysplasia, moderate dysplasia and severe dysplasia. Statistical analysis was performed by using chi-square test and a probability of P < 0.05 was considered as significant. Result and Conclusion: Overexpression of this oncoprotein was seen as the grade of epithelial dysplasia increased, suggesting the role of this oncoprotein in early stages of tumor progression. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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