Molecular Aspects of Anti-Atherosclerotic Effects of Short Peptides.

Autor: Khavinson, V., Lin'kova, N., Evlashkina, E., Durnova, A., Kozlov, K., Gutop, O.
Předmět:
Zdroj: Bulletin of Experimental Biology & Medicine; Nov2014, Vol. 158 Issue 1, p159-163, 5p
Abstrakt: We studied molecular mechanisms of the vasoprotective effects of tripeptide T-38 and dipeptide RR-1. Short peptides T-38 and the RR-1 activate the processes of cell renewal in organotypic and dissociated cultures of vascular cells during aging by increasing the expression of Ki-67 and reducing the synthesis of p53 protein. T-38 and RR-1 reduce the synthesis of E-selectin, adhesion molecule involved in the formation of atherosclerotic plaques. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index