| Autor: |
Yerande, Swapnil G., Ghaisas, Amruta B., Newase, Kiran M., Wang, Wei, Wang, Kan, Dömling, Alexander |
| Předmět: |
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| Zdroj: |
Journal of Heterocyclic Chemistry; Nov2014, Vol. 51 Issue 6, p1752-1756, 5p |
| Abstrakt: |
Herein, we report an efficient method for preparation of 3-phenylamino-5-aryl/alkyl-1,2,4-oxadiazole by (3+2) of amidinothioureas with binucleophilic hydroxylamine hydrochloride in the presence of mercury (II) chloride. Desired 3-phenylamino-5-aryl/alkyl-1,2,4-oxadiazole was prepared in good to moderate yields. On the basis of the literature precedence, the mechanism for the formation of 3-phenylamino-5-aryl/alkyl-1,2,4-oxadiazole is proposed. The synthesized compounds were tested for their and showed promising inhibition of Gram-positive bacteria ( Staphylococcus aureus) and fungi ( Candida albicans). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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