The effects of imipramine and the inhibitor of prolylendopeptidase benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine on the levels of monoamines and their metabolites in the brain of rats with an experimental anxious-depressive state.

Autor: Khlebnikova, N., Kushnareva, E., Kudrin, V., Krupina, N.
Zdroj: Neurochemical Journal; Oct2014, Vol. 8 Issue 4, p271-276, 6p
Abstrakt: Using a model of the anxious-depressive state in rats induced by postnatal administration of the inhibitor of dipeptidylpeptidase-IV, methionyl-2(S)-cyanopyrrolidine, we revealed an increase in the metabolism of 5-OTP (which was evaluated using the 5-OIAA/5-OTP ratio) in the frontal cortex. In addition, we found a decrease in DA metabolism in the hypothalamus, which was seen as a decrease in levels of the HVA and (DOPAC + HVA)/DA ratio, and a decrease in the DA content in the hippocampus. A 10-day administration of the tricyclic antidepressant imipramine at a dose of 10 mg/kg or a non-competitive inhibitor of prolylendopeptidase, benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine, at a dose of 2 mg/kg prevented the development of depressive symptoms and alterations of monoamines and their metabolism in the rat brain. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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