| Autor: |
Nakajima, Akira, Ueda, Yuto, Matsuda, Emiko, Sameshima, Hiroshi, Ikenoue, Tsuyomu |
| Zdroj: |
Applied Magnetic Resonance; Dec2014, Vol. 45 Issue 12, p1417-1425, 9p |
| Abstrakt: |
The intracerebral antioxidant ability of rats in 8 and 21 % oxygen (O) atmospheres was estimated from the decay of the electron spin resonance (ESR) signal of 3-methoxycarbonyl-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl (PCAM), blood-brain-barrier (BBB)-permeable stable cyclic nitroxide, in the perfusate from the brain of the rats using the microdialysis-ESR method. The decay rate of PCAM in 8 % O was about 1.5 times that in 21 % O. The oxidation of the perfusate by potassium hexacyanoferrate(III) [KFe(CN)] indicated that PCAM in the rats in 8 % O was more greatly reduced to its hydroxylamine than that in 21 % O. These results showed that the intracerebral antioxidant ability of rats in 8 % O was larger than that in 21 % O. The metal-catalyzed autooxidation of ascorbic acid should be one of the potent factors affecting the intracerebral antioxidant ability of rats in the atmosphere containing different oxygen concentrations. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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