| Autor: |
Xu, Xiaojin, Araki, Koichi, Li, Shuzhao, Han, Jin-Hwan, Ye, Lilin, Tan, Wendy G, Konieczny, Bogumila T, Bruinsma, Monique W, Martinez, Jennifer, Pearce, Erika L, Green, Douglas R, Jones, Dean P, Virgin, Herbert W, Ahmed, Rafi |
| Předmět: |
|
| Zdroj: |
Nature Immunology; Nov2014, Vol. 15 Issue 12, p1152-1161, 10p, 8 Graphs |
| Abstrakt: |
The importance of autophagy in the generation of memory CD8+ T cells in vivo is not well defined. We report here that autophagy was dynamically regulated in virus-specific CD8+ T cells during acute infection of mice with lymphocytic choriomeningitis virus. In contrast to the current paradigm, autophagy decreased in activated proliferating effector CD8+ T cells and was then upregulated when the cells stopped dividing just before the contraction phase. Consistent with those findings, deletion of the gene encoding either of the autophagy-related molecules Atg5 or Atg7 had little to no effect on the proliferation and function of effector cells, but these autophagy-deficient effector cells had survival defects that resulted in compromised formation of memory T cells. Our studies define when autophagy is needed during effector and memory differentiation and warrant reexamination of the relationship between T cell activation and autophagy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
