Prevention of Early Menopause Study (POEMS): is it possible to preserve ovarian function by gonadotropin releasing hormone analogs (GnRHa)?

Autor:	Gerber, B., Ortmann, O.
Předmět:	PREMATURE menopause DRUG therapy PREMATURE ovarian failure OVARIAN diseases HEALTH outcome assessment GONADOTROPIN releasing hormone CHEMICAL derivatives
Zdroj:	Archives of Gynecology & Obstetrics; Dec2014, Vol. 290 Issue 6, p1051-1053, 3p, 1 Chart, 2 Graphs
Abstrakt:	Introduction: The effect of GnRHa in the preservation of ovarian function during a modern chemotherapy is still under discussion. Material and Method: In this News and Views article, we discuss the benefits and weaknesses of the recently presented POEMS. Results: The POEM study demonstrated an increased resumption of ovarian function and pregnancy rate after using GnRHa. GnRHa in HR-negative patients led to a significant increase in disease free and overall survival, with those effects being inexplicable. Weaknesses of the trial were prematurely close due to lack of recruitment, a drop-out rate of 38 % during follow-up and definition of hormone receptor negativity by <10 % positive stained cells. Conclusion: Even after POEMS, there is no additional clarity regarding preservation of ovarian function during chemotherapy by GnRHa. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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