| Autor: |
LI Yang, QIN Qin, REN Bei, ZHAO Lili, MAO Yongmin, ZHENG Ping |
| Předmět: |
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| Zdroj: |
Tianjin Medical Journal; Sep2014, Vol. 42 Issue 9, p903-908, 6p |
| Abstrakt: |
Objective To observe the association between adiponectin gene polymorphism, serum adiponectin levels with the incidence of coronary artery disease (CAD) and the severity of coronary artery stenosis in patients with essential hypertension (EH). Methods A total of 414 patients with EH (234 cases with CAD and 180 cases without CAD) and 185 control subjects were recruited in this study. Serum adiponectin levels were measured by enzyme-linked immunosorbent assay (ELISA). Adiponectin single-nucleotide polymorphisms rs266729, rs7649121, rs1501299 and rs3774262 were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results Serum adiponectin levels were significantly lower in EH with CAD group than those in control group and EH without CAD group. Adiponectin SNP rs7649121 AT genotype reduced the risk of CAD compared with AA genotype (adjusted OR=0.566, 95% CI 0.346-0.925, P=0.023). Logistic regression analysis showed that age and LDL-C were risk factors of CAD, and adiponectin was the protective factor for CAD in EH patients. The severity of coronary artery stenosis was negatively related to the level of adiponectin. Adiponectin levels were not affected by the adiponectin gene polymorphism. Conclusion The decreased serum adiponectin level was the independent risk factor for CAD in EH patients, which was negatively related to the severity of coronary artery stenosis. Adiponectin SNP rs7649121 may contribute to the risk factors of CAD in EH patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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