One-Pot, Three-Component Synthesis of Novel Pyrroloacridinones via Intramolecular ipso Dearomatization-Intramolecular Aza-Michael Addition Sequence.

Autor: Rozhkova, Yuliya S., Galata, Kristina A., Gorbunov, Alexey A., Shklyaev, Yurii V., Ezhikova, Marina A., Kodess, Mikhail I.
Předmět:
Zdroj: Synlett; 2014, Vol. 25 Issue 18, p2617-2623, 7p
Abstrakt: A one-pot, three-component synthesis of novel pyrroloacridinones from a set of alkoxy arenes and 2,6-dialkylphenols, isobutyric aldehyde, and 2-aminobenzonitrile is described. We have demonstrated the efficacy of the combination of intramolecular electrophilic ipso dearomatization of suitable aromatic compounds leading to spiro-substituted cyclohexa-2,5-dienones and intramolecular aza-Michael addition for the preparation of complex azaheterocyclic systems. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index