| Autor: |
Abreu, Mónica, Carvalheiro, Helena, Rodrigues-Sousa, Tiago, Domingos, António, Segorbe-Luis, António, Rodrigues-Santos, Paulo, Souto-Carneiro, M. |
| Předmět: |
|
| Zdroj: |
Clinical & Experimental Medicine; Nov2014, Vol. 14 Issue 4, p423-429, 7p |
| Abstrakt: |
The function of B cells in the immune response against Mycobacterium tuberculosis ( Mtb) is still regarded as secondary, although major findings in mouse models of tuberculosis (TB) support their participation as regulators and antibody producers. However, studies in cohorts of TB or multidrug-resistant TB (MDR-TB) patients have failed to clearly identify changes in the circulating B cell pool. Therefore, in the present study we aimed at identifying alterations in the different B cell subpopulations in peripheral blood samples of HIV-negative pulmonary MDR-TB patients when compared to healthy donors. The data show, for the first time, that MDR-TB patients, similarly to what has been observed in other chronic inflammatory diseases, have a much lower frequency of peripheral blood unswitched IgDCD27 memory B cells. Equally novel are the findings that in MDR-TB patients there is a reduction in the circulating plasma cell pool and that in MDR-TB there is an increased frequency of circulating type 1 transitional IgDCD38, CD69 and TLR9 B cells. These results document disease-related shifts in peripheral blood B cell subsets in MDR-TB and suggest that such changes should be taken into account when designing new strategies to boost the cellular and humoral immune response against Mtb. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink