| Abstrakt: |
1. The disposition kinetics and the plasma availability of moxifloxacin were investigated in Japanese quails (Coturnix japonica) following different routes of administration at 5 mg/kg body weight. 2. Tissue residue profiles (liver, kidney, lung and muscle) and plasma were also studied after multiple intramuscular and oral administrations of 5 mg/kg body weight, once daily for 5 consecutive days. 3. Following intravenous injection, plasma concentration–time curves were best described by a two-compartment open model. 4. After intramuscular and oral administration of moxifloxacin, the peak plasma concentrations (Cmax) were 2.14 and 1.94 μg/ml and were obtained at 1.40 and 1.87 h (Tmax), post administration, respectively. 5. The systemic bioavailabilities following intramuscular and oral administration, respectively, of moxifloxacin were 92.48 and 87.94%. 6. Tissue concentrations following i.m. and p.o. administration were highest in liver and kidney, respectively, and decreased in the following order: plasma, lung and muscle. No moxifloxacin residues were detected in tissues and plasma after 120 h after i.m. or oral administration. [ABSTRACT FROM AUTHOR] |
