T richosanthes Cucumerina Fruit Extenuates Dyslipidemia, Protein Oxidation, Lipid Peroxidation and DNA Fragmentation in the liver of high-fat diet-fed rats.

Autor: Ajiboye, Taofeek O., Akinpelu, Sakirat A., Muritala, Hamdalat F., Ogunbode, Simiat M., Adeleye, Abdulwasiu O., Oladiji, Adenike T., Oloyede, Oyelola B.
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Zdroj: Journal of Food Biochemistry; Oct2014, Vol. 38 Issue 5, p480-490, 10p
Abstrakt: The effect of Trichosanthes cucumerina fruit pulp extract on dyslipidemia, protein oxidation, lipid peroxidation and DNA fragmentation in the liver of high-fat diet-fed rats was investigated. High-fat diet-mediated alterations in liver and serum total cholesterol, triacylglycerol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, alkaline phosphatase, and alanine and aspartate aminotransferase were significantly ( P < 0.05) reversed by the T . cucumerina pulp extract. The extract increased the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose 6-phosphate dehydrogenase in the mitochondria and post-mitochondria fractions of rat liver. The increase significantly ( P < 0.05) attenuated high-fat diet-mediated reductions in antioxidant enzyme activities. High-fat diet-mediated elevation in the levels of conjugated dienes, lipid hydroperoxides, malondialdehyde, protein carbonyl and DNA fragmentation in rat liver was dose-dependently lowered by the extract. The data obtained from this study showed that the T . cucumerina fruit pulp extract palliated high-fat diet-mediated dyslipidemia, protein oxidation, lipid peroxidation and DNA fragmentation in rats. Practical Applications T richosanthes cucumerina fruit pulp can be developed into a nutraceutical product to treat liver disorders. It can also be consumed at home and as substitute to L ycopersicon esculentum ( L.) Mill. The fruit pulp of T . cucumerina is sweet tasting, aromatic, deep red in color and does not go sour as quickly as paste of L . esculentum. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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