Central hydrogen sulphide mediates ventilatory responses to hypercapnia in adult conscious rats.

Autor:	Silva, G. S. F., Soriano, R. N., Kwiatkoski, M., Giusti, H., Glass, M. L., Branco, L. G. S.
Předmět:	HYDROGEN sulfide HYPERCAPNIA LABORATORY rats CHEMICAL senses CYSTATHIONINE beta-synthase CYSTATHIONINE gamma-lyase MICROINJECTIONS OXYGEN consumption
Zdroj:	Acta Physiologica; Nov2014, Vol. 212 Issue 3, p239-247, 9p, 2 Diagrams, 2 Charts, 4 Graphs
Abstrakt:	Aim Hydrogen sulphide (H2S) is endogenously produced and plays an important role as a modulator of neuronal functions; however, its modulatory role in the central CO2 chemoreception is unknown. The aim of the present study was to assess the role of endogenously produced H2S in the ventilatory response to hypercapnia in adult conscious rats. Methods Cystathionine β-synthase ( CBS) and cystathionine γ-lyase ( CSE) inhibitors (aminooxyacetate: AOA and propargylglycine: PAG respectively) and a H2S donor (sodium sulphide: Na2S) were microinjected into the fourth ventricle (4V). Ventilation ( [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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