| Autor: |
Lucarini, Rodrigo, nio^Bernardes, Wagner Ant, Tozatti, Marcos Gomide, Filho, Ademar Alves da Silva, e Silva, Márcio Luis Andrade, Momo, Claudia, Crotti, Antônio Eduardo Miller, Martins, Carlos Henrique Gomes, Cunha, Wilson Roberto |
| Předmět: |
|
| Zdroj: |
Emirates Journal of Food & Agriculture (EJFA); 2014, Vol. 26 Issue 10, p878-884, 7p |
| Abstrakt: |
The hydroalcoholic extract of the leaves of Rosmarinus officinalis (HE), a species of medicinal value, and itsconstituent rosmarinic acid (RA) were evaluated for hepatoprotective in the acetaminophen-induced liverdamage model. Groups of Wistar albino rats (n=6) were pre-administered with HE (100, 250 and 500 mg/kg,p.o.) and RA (10, 25 and 50 mg/kg, p.o.) prior to a single dose of acetaminophen (APAP, 600 mg/kg bodyweight; p.o). The hepatoprotective activity of HE extract was observed through histopathological analysis andreduction of the level of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkalinephosphatase (ALP). These observations were comparable to the normal group prior to APAP administration.Group that was treated with APAP alone exhibited high levels of transaminases and ALP. The obtained resultsfrom the present study suggested that HE may prevent APAP-induced hepatic injuries. RA did not displayedsignificant hepatoprotective activity against APAP-induced liver damage. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
