Vitamin D as a Neurosteroid Affecting the Developing and Adult Brain.
| Autor: | Groves, Natalie J., McGrath, John J., Burne, Thomas H. J. |
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| Předmět: |
MENTAL depression risk factors
MENTAL illness prevention SCHIZOPHRENIA risk factors NEURODEGENERATION BRAIN metabolism STROKE risk factors VITAMIN D metabolism AGING APOPTOSIS BRAIN injuries CELLULAR signal transduction DIETARY supplements DOPAMINE GENE expression MICE NEUROPHYSIOLOGY RATS RESEARCH VITAMIN D deficiency DISEASE exacerbation ADULTS PREVENTION |
| Zdroj: | Annual Review of Nutrition; 2014, Vol. 34, p117-141, 25p |
| Abstrakt: | Vitamin D deficiency is prevalent throughout the world, and growing evidence supports a requirement for optimal vitamin D levels for the healthy developing and adult brain. Vitamin D has important roles in proliferation and differentiation, calcium signaling within the brain, and neurotrophic and neuroprotective actions; it may also alter neurotransmission and synaptic plasticity. Recent experimental studies highlight the impact that vitamin D deficiency has on brain function in health and disease. In addition, results from recent animal studies suggest that vitamin D deficiency during adulthood may exacerbate underlying brain disorders and/or worsen recovery from brain stressors. An increasing number of epidemiological studies indicate that vitamin D deficiency is associated with a wide range of neuropsychiatric disorders and neurodegenerative diseases. Vitamin D supplementation is readily available and affordable, and this review highlights the need for further research. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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