Autor: |
J. I. N. Oliveira, E. L. Albuquerque, U. L. Fulco, P. W. Mauriz, R. G. Sarmento, E. W. S. Caetano, V. N. Freire |
Zdroj: |
Europhysics Letters; Sep2014, Vol. 107 Issue 6, p1-1, 1p |
Abstrakt: |
The charge transport properties of single-stranded microRNAs (miRNAs) chains associated to autism disorder were investigated. The computations were performed within a tight-binding model, together with a transfer matrix technique, with ionization energies and hopping parameters obtained by quantum chemistry method. Current-voltage curves of twelve miRNA chains related to the autism spectrum disorders were calculated and analysed. We have obtained both semiconductor and insulator behavior, and a relationship between the current intensity and the autism-related miRNA bases sequencies, suggesting that a kind of electronic biosensor can be developed to distinguish different profiles of autism disorders. [ABSTRACT FROM AUTHOR] |
Databáze: |
Complementary Index |
Externí odkaz: |
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