Antihyperlipidemic Effects of Rhapontin and Rhapontigenin from Rheum undulatum in Rats Fed a High-Cholesterol Diet.
| Autor: | Sung-Pil Jo, Jeong-Keun Kim, Young-Hee Lim |
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| Předmět: |
FATTY liver prevention
HYPERLIPIDEMIA ALTERNATIVE medicine ANALYSIS of variance ANIMAL experimentation ASPARTATE aminotransferase BIOPHYSICS PHYSICAL & theoretical chemistry CHOLESTEROL COMPARATIVE studies DOSE-effect relationship in pharmacology CHOLESTEROL content of food HIGH density lipoproteins HISTOLOGICAL techniques LOW density lipoproteins RESEARCH methodology MEDICINAL plants RATS RESEARCH funding PLANT roots STATISTICS PLANT extracts DATA analysis ALANINE aminotransferase DATA analysis software DESCRIPTIVE statistics SIMVASTATIN PREVENTION |
| Zdroj: | Planta Medica; 2014, Vol. 80 Issue 13, p1067-1071, 5p |
| Abstrakt: | Rhapontin was purified from a methanol extract from the roots of Rheum undulatum, and rhapontigenin was produced by an enzymatic transformation of rhapontin. Rats were fed a high-cholesterol diet to induce hyperlipidemia, followed by oral treatment with rhapontin or rhapontigenin (1-5mg/kg/day). Rhapontin and rhapontigenin treatment resulted in a significant (p < 0.05) dose-dependent decrease in the serum lipid level, while the high-density lipoprotein cholesterol level increased slightly compared with the experimental control. Furthermore, rhapontin and rhapontigenin treatment improved the pathological characteristics of the degenerating fatty liver in high-cholesterol diet-induced hyperlipidemic rats dose-dependently. Aspartate aminotransferase and alanine aminotransferase levels in rhapontinand rhapontigenin-treated hyperlipidemic rats were not significantly different from those in the control. These results indicate that rhapontin and rhapontigenin can be used as potent antihyperlipidemic agents. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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