| Autor: |
Salerno, Agata, Vacante, Marco, Pollina, Donatella, Stancanelli, Benedetta, Martini, Silvia, David, Ezio, Malatino, Lorenzo |
| Předmět: |
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| Zdroj: |
British Journal of Medical Practitioners; Jun2014, Vol. 7 Issue 2, p16-18, 3p, 1 Color Photograph, 3 Black and White Photographs |
| Abstrakt: |
6-Thioguanine (6-TG) is being given to patients with Crohn's disease failing conventional immunosuppression, but cases of hepatotoxicity have been reported. We report the case of a patient who developed acute sinusoidal obstruction syndrome after 3 months of successful 6-TG treatment. A complete regression of liver injury was observed after withdrawal of 6-TG. Our case-report underscores the risk of hepatic injury due to the administration of 6-TG for Crohn's disease. We strongly recommend alternative therapeutic options in patients intolerant or resistant to conventional thiopurines. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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