Congenital heart defects and maternal fever: systematic review and meta-analysis.
| Autor: | Shi, Q Y, Zhang, J B, Mi, Y Q, Song, Y, Ma, J, Zhang, Y L |
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| Předmět: |
HEART ventricle diseases
ANALYSIS of variance CHI-squared test CONFIDENCE intervals CONGENITAL heart disease FEVER INFORMATION storage & retrieval systems MEDICAL databases MEDICAL information storage & retrieval systems MATERNAL health services MEDLINE META-analysis ONLINE information services FIRST trimester of pregnancy RESEARCH funding SYSTEMATIC reviews DATA analysis software ODDS ratio |
| Zdroj: | Journal of Perinatology; Sep2014, Vol. 34 Issue 9, p677-682, 6p, 1 Diagram, 6 Charts |
| Abstrakt: | OBJECTIVE:To systematically review and meta-analyze the relation between maternal fever in the first trimester and congenital heart defect (CHD) in offspring.STUDY DESIGN:We searched PubMed (1977-2012), Embase (1974-2012) and the Cochrane Library (2012) databases to identify relevant articles. Random effects model were performed, with the conduction of subgroup analysis.RESULT:Meta-analysis yielded a pooled odds ratio of 1.53 (95% confidence interval=1.36 to 1.73) for the magnitude of the relation between maternal fever in the first trimester and CHD in offspring. As to subgroup analysis, it is associated with ventricular septal defects (VSDs) and right obstructive defects.CONCLUSION:Our analysis suggests that maternal fever in the first trimester is the risk factor of congenital heart diseases in offspring. Through the subgroup analysis, we find that exposure to maternal fever is the risk factor of VSD and right obstructive defects. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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