FIRST REPORT ON OTOTOXICITY OF MEGLUMINE ANTIMONIATE.

Autor: VALETE-ROSALINO, Claudia Maria, ARAUJO-MELO, Maria Helena, de Oliveira BEZERRA, Débora Cristina, de BARCELOS, Renata Oliveira, de MELO-FERREIRA, Vanessa, de Sousa TORRACA, Tania Salgado, da Costa MARTINS, Ana Cristina, MOREIRA, Joäo Soares, VARGAS, Mirian Catherine Melgares, BRAGA, Frederico Pereira Bom, de Matos SALGUEIRO, Mariza, SAHEKI, Mauricio Naoto, SCHUBACH, Armando Oliveira
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Zdroj: Revista do Instituto de Medicina Tropical de São Paulo; Sep/Oct2014, Vol. 56 Issue 5, p439-442, 4p
Abstrakt: Introduction: Pentavalent antimonials are the first drug of choice in the treatment of tegumentary leishmaniasis. Data on ototoxicity related with such drugs is scarcely available in literature, leading us to develop a study on cochleovestibular functions. Case Report: A case of a tegumentary leishmaniasis patient, a 78-year-old man who presented a substantial increase in auditory threshold with tinnitus and severe rotatory dizziness during the treatment with meglumine antimoniate, is reported. These symptoms worsened in two weeks after treatment was interrupted. Conclusion: Dizziness and tinnitus had already been related to meglumine antimoniate. However, this is the first well documented case of cochlear-vestibular toxicity related to meglumine antimoniate. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index