| Autor: |
Hudson, Harry R., Lee, Rosalind J. |
| Předmět: |
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| Zdroj: |
Phosphorus, Sulfur & Silicon & the Related Elements; Aug2014, Vol. 189 Issue 7/8, p1149-1155, 7p |
| Abstrakt: |
Reports on the anticancer activity of representative α-aminophosphonic acid derivatives are briefly reviewed, with comments where possible on modes of action. Preliminary in vitro screening results are also presented for selected dialkyl α-aryl (or heteroaryl)-α-(diphenylmethylamino)methanephosphonates against the National Cancer Institute (NCI) 60-cell line panel of human tumor cells, which showed average response parameters for active compounds of GI50between 4.81 × 10−6and 2.40 × 10−5M, TGI between 1.88 and 6.28 × 10−5M, and LC50between 5.71 and 9.37 × 10−5M. The highest activity was shown by the α-phenyl compound for which GI5010−7M was recorded against leukemia cell line MOLT-4. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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